NEW LOOK COMING SOON!
Estro Vitality, was designed to promote a smoother, more hydrated look and feel, while fitting easily into your existing skincare routine. No fragrance. No parabens. No mineral oil. No complicated 14-step situation. Just a clean, carefully crafted, low-dose estradiol cream made for this stage of life.
What you may notice
Skin that feels more hydrated. A smoother, softer look and feel. A more refreshed appearance. That subtle “wait, my skin feels better” moment.
How to Use:
- Face and neck: Apply 1–2 pumps once daily. Massage gently until fully absorbed.
- Body: Apply up to 2 pumps to inner forearms twice daily.
- Works well layered — apply after serums, before SPF.
- One bottle = a 70+ day supply at suggested daily use.
Always consult with a qualified healthcare provider before use, particularly if you have any health conditions or are taking other medications.
Download our FREE Product User Guide Download our Quick Start Guide
* International shipping is unavailable for this product.
Frequently Asked Questions
Can I use this as part of my existing skincare routine?
Yes. The formula layers well under moisturizer and SPF. Many customers apply it right after cleansing as their first step, or after a Vitamin C serum.
How long before I notice results?
It varies. Some customers notice their skin looks and feels different within the first week or two. Others find results become more visible over several weeks of consistent use.
Can I use this on areas other than my face?
Yes — it’s designed for both face and body. Apply to the face, neck, and inner forearms as directed. Consult your healthcare provider if you have questions about your specific application routine.
Can I combine this with other products?
If you are using other topical or systemic products, we recommend discussing this with your healthcare provider before adding anything new to your routine.
Is this product right for me?
We recommend consulting a qualified healthcare provider before starting any new hormone-containing cosmetic, especially if you have a personal or family history of hormone-sensitive conditions.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.
Lucille S. –
From the start of using product help me Wright away hot flashes and night sweats improve greatly. I’m very thankful.
Shelli O. –
Thank you so much for making an OTC estradiol cream! I’ve been using it for the last month along with the Progest Calm and my symptoms are already much better. Most notably my hormonal bloating is practically gone, and my mood has been much more stable and consistently happy throughout the month. I will definitely keep these products in my routine!
Martha C. –
I’ve been using Estro Vitality for about a month now. It goes on silky smooth and soaks in beautifully. I’m applying it every morning and I think its helping me with reduced hot flashes.
Lisa K. –
Great product and just what I needed for relieving peri monophase symptoms.
Tina N. –
The order and shipping process can be much improved. I did not receive the tracking. Umber in their email that it had shipped. I sent an email to ask and it took days for someone to respond.
With that said, the serum works well. Wish I had known that estrogen consists of several hormones, one of which is estradiol. I listen to Karen podcast a lot and don’t think this ever came up. It wasn’t until I listened to Dr Brickman who clearly explained this. I promptly looked for estradiol and ordered it.
Marsha A. –
I haven’t used this long enough for results, but it feels good on my skin and doesn’t irritate it at all.
Andrea B. –
I love the feel of the cream when putting it on.
Sue T. –
Love it! Just what I needed. Love the results.
Lauriejean C. –
I have been looking for straight Estradiol. While this dose is low for therapeutic dosing if one is trying to dose once a day, I do like that at this lower dose, I can easily mimic a daily dose. Spread over the day.
Lisa H. –
Took about 6 weeks, but feeling like myself more and more!
Alison S. –
Sure helps with my night sweats!
Lara S. –
I use it daily, and the progesterone from day 15 until my period starts. I’m so happy to have access to this high quality HRT. Life changing
Zora B. –
OMG, I have been looking for a good safe and effective estradiol cream online and I don’t trust anyone but Karen Martel. Her estradiol is super clean, goes on really easily and is nicely absorbed.
Night sweats. Gone!
Thank you Karen for coming up with such a great formula.
Lisa B. (verified owner) –
Hey! I love the product. I add it as a supplement to the biest that my doc prescribes to help with hair loss. The downside is the very long shipping time. I ordered on January 17 and received it on January 3rd. More than two weeks is a long time for delivery!
Diane H. –
This product is very easy to use. My body absorbs it with no issues.
Melissa H. –
It works amazing!
Sofia G. –
Love having that extra boost of estradiol. I use it with my twice weekly patch on day three because the patch doesn’t really last as long as it’s supposed to. I also use it on my hormone boost days. Thanks for making a clean trustworthy product!
Jeraldine M. –
I haven’t been on it long enough to have huge results, but starting to feel more energy.
Kerry E. –
Really smooth and rubs in nicely. I haven’t retested my DUTCH yet, so I don’t know if my hormones are changing from it per se. I am also using the progesterone cream, and compounded progesterone capsules only in my luteal phase. I was very very low in estradiol, especially in my luteal phase (and testosterone all the time, and progesterone was a bit low also). I am rubbing this cream on my chest and my upper arms to hopefully tighten that skin and reduce fine lines & wrinkles. :))
Mary H. –
I’ve used Estradiol Vitality for only a few months but it has help me increase my estradiol, I’m on the patch but needed just a little extra and this has helped me feel better. Great product!
Danielle M. –
Ive been using an estrogen cream from a different company. It is gritty and I hated it under my makeup. With your cream, my makeup goes on much smoother, i need no primer…. it just overall makes my face look better!
Kristen U. –
I found that taking oral progesterone upset my stomach. After learning from Karen on her podcast, The Hormone Solution, that oral has to be processed through the liver, I decided to give this a try. Wow! No upset stomach and I’m sleeping great! I bought the Estrogen cream as well but haven’t tried it yet as I’m currently using the patch until my prescription runs out.
Tanya A. –
It’s silky and luxurious!
Elizabeth K. –
I haven’t noticed much difference.
Miosotis R. –
My skin is looking so much brighter.
Rita M. (verified owner) –
I like the cream a lot. My only complaint is the 1 pump amount varies tremendously. Most likely just the bottle I happened to get.
Julia M. –
I’m very new to HRT but has been using Estrogen cream as an addition to the patch to boost my estrogen on certain days of the months and I think it’s been working because my breast got a bit tender which I think is expected at the beginning of the journey to the HRT lifestyle. We’ll see what happens at the end of my month expecting to have my period. I also use progesterone cream and it’s been absolutely wonderful. I sleep like a baby now. Don’t have to worry if I’ll fall asleep in the middle of the night. Thank you, Karen.
Stephanie S. –
Lovely cream. Haven’t been using it quite long enough to determine results for comment, but am pleased with the ordering and shipping processes, and with the product itself thus far! Will be keeping my subscription!
Lori W. –
I’m thrilled with my Estradiol cream. The texture is rich and thankfully no aroma. I use it twice a day to keep my estrogen balanced.
Sarah P. (verified owner) –
Excellent lotion. Works much better than the previous Estrogen lotion I had been using.
Kristen U. –
I was hesitant to use topical estradiol because I thought it would be messy and a hassle. Thankfully I was so wrong! The pump is so easy to use with no mess. It dissolves quickly and doesn’t have any odor to it. I’m looking forward to also trying Karen’s new estradiol oil she is coming out with soon!
Ann W. (verified owner) –
OK, to be utterly frank about menopause, …… I finally found out what sandpaper sex was. OMG, Karen. I panicked. Rather than wait a long time for a physician appt, I grabbed your .25 Estrodial. I applied 1/2 pump daily within the lower third of the vagina. The rest according to directions. Two weeks later I am better than fine. I am so grateful for your products.
Joanne S. –
Just love the Estro Vitality! I’m sleeping better, my memory has improved and I’ve got more energy.
Thank you Karen. I’m going to continue using this wonderful product!
Joanne
Collern L. –
I’ve been useless for about two weeks and I have noticed that my pores are not as visible. My skin feels like a baby‘s butt lol and just overall I just look up a lot more radiant.
Holly B. (verified owner) –
Amazing product! Lovely and easy application and rubs in so quickly without any residue or sticky feeling. Pure ingredients and the most fantastic Customer Service Team if you have any questions.
Melissa C. (verified owner) –
It’s been great
Cyn H. –
Within a few days of using one pump a day my hot flashes stopped. I didn’t have any side effects from starting hormones with one pump, I wasn’t moody, no break outs etc.
I am now increasing to 2 pumps a day.
Cindy M. –
I could tell that the Estro Vitality was working based on my mood, but I was REALLY convinced once I had run out of the cream for 3-4 weeks. That was a disaster! My mood swings, sadness, and inability to cope were so heightened – just like being back at the start of my menopause journey. I didn’t piece it together until I spoke with my functional nutritionist. I’m a huge advocate and won’t go without my cream ever again.
Stacey O. –
Love the new pump that streamlines how much cream comes out for controlled use.
Jillian E. –
I’ve only had this for less than a mont. I am using it on my face and neck. More will be revealed.
Donna Jordan (verified owner) –
Love this product. Love that I can use a product that is transdermal
Joni Michael (verified owner) –
This estradiol cream absorbs quickly, and it definitely relieves my menopausal symptoms.
LayneJayne –
Amazing product. I feel like myself again! I would never want to be without it.
Jennifer Bunger (verified owner) –
I have been using the Estro Vitality Renewal Cream for almost a year now. I found it and the Progesterone cream after searching for alternatives to prescription hormones that weren’t a great fit. The cream is easy to apply and I believe it has helped me feel better in menopause. I am so thankful it’s available!
Leesa Thao –
Has been working great
Dora Alicia Quiñones (verified owner) –
Fabulosa!! Me siento mucho mejor de mejor ánimo sin bochornos.
ShelleyW –
I have been using this product for several months. I haven’t seen any results. I wish the delivery system was more creamed based. This product is more like a lotion.
Olga Lyons –
It works. The amount of cream to use to get the dose is too much.
Rheanon Short –
This stuff absolutely gets the job done especially when you are in the beginning of perimenopause. It also has a great texture and smell!
Beth Goldberg –
Really lovely high quality unscented (amen!) cream.
In a world of over perfumed estrogen/progesterone creams, this is a nice find. Has improved skin texture and creepy crepe skin. I use this as a cosmetic face base, and a pea size amount works wonders. Saw results immediately!
Shannon Boyd –
I love having Estro Vitality on hand. There are times when I need a bit more estradiol, and Estro Vitality is perfect.
Cyn H. –
Within a few days of using one pump a day my hot flashes stopped. I didn’t have any side effects from starting with one pump, I wasn’t moody, no break outs etc.
Missy L. (verified owner) –
Anonymous (store manager) –
I love having Estro Vitality on hand. There are times when I need a bit more estradiol, and Estro Vitality is perfect.
Anonymous (store manager) –
I use this and the other Estro cream as topical face base cosmetics. What an instant improvement to tone, texture, and glow.
Anonymous (store manager) –
Really lovely high quality unscented (amen!) cream.
In a world of over perfumed estrogen/progesterone creams, this is a nice find. Has improved skin texture and creepy crepe skin. I use this as a cosmetic face base, and a pea size amount works wonders. Saw results immediately!
Rheanon Short (store manager) –
This stuff absolutely gets the job done especially when you are in the beginning of perimenopause. It also has a great texture and smell!
Olga Lyons (store manager) –
It works. The amount of cream to use to get the dose is too much.
Dora Alicia Quiñones (store manager) –
Fabulosa!! Me siento mucho mejor de mejor ánimo sin bochornos.
Anonymous (store manager) –
I have been using the Estro Vitality Renewal Cream for almost a year now. I found it and the Progesterone cream after searching for alternatives that weren’t a great fit. The cream is easy to apply and I believe it has helped me feel better in menopause. I am so thankful it’s available!
Peggy F. (verified owner) –
I am feeling and seeing the results of this product.
Dana A. (verified owner) –
This is my first month using the Estro Vitality cream. Not sure if the cause but since starting this product my hot flashes have increased in intensity. Hoping this calms back down.
Nicolle –
I LOVED this product. Truly changed my day to day. Thank you so much!
Lori T. (verified owner) –
An easy way to get my Estrogen. It works!