The Formula
Each pump delivers a precise dose of BiEST — Micronized Estradiol USP and Micronized Estriol USP — in a rich yet lightweight base designed to absorb quickly and layer beautifully under your existing routine.
How to Use
- Face: Apply 1–2 pumps to face and neck once daily. Massage gently until fully absorbed.
- Body: Apply up to 2 pumps to inner forearms twice daily.
- 1 pump = 0.25mg Estradiol + 1mg Estriol
- 70+ day supply with suggested daily use
Works well layered — apply after Vitamin C or other serums, before SPF.
Your skin has a story. This cream helps it look like the best chapter.
Download our FREE Product User Guide Download our Quick Start Guide
* International shipping is unavailable for this product.
Frequently Asked Questions
Can I use this as part of my existing skincare routine?
Yes. The formula layers well. Apply it after any water-based serums and before moisturizer or SPF. Many customers apply it right after cleansing as their first step.
Can I use this on areas other than my face?
Yes — it can be applied to the face, neck, and inner forearms. Use as directed and consult your healthcare provider if you have questions about application area.
Why pair this with a progesterone cream?
We recommend it. If you’re using any topical estrogen cosmetic, pairing it with a progesterone cream like our Progest Calm is something many practitioners advise. Your healthcare provider can help guide you on what’s right for your individual situation.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Always consult with your healthcare provider before starting any new supplement or skincare product.
Kizzy L. –
This cream gave me my “25 year old” skin back ! It’s amazing!
Rachael A. (verified owner) –
I am LOVING this face cream!! My sister (and others) have recently commented on how my skin “looks so fresh and smooth” since I have been applying this BiEst cream (for about 3 months now). I am 50yo (peri-menopausal)- and do not do anything “extra” in terms of my skin care routine. I do not do botox, chemical peels, lasers, etc. I am all about restoring what my body is delpeted with natural modalities and supplements. I’ve been learning so so much about Bioidentical HRT- which has lead me to Karen Martel’s work/podcasts and store! Thank YOU Karen and your amazing team for creating such an wonderful topical cream (that works!) for my face. Much love to you all !
Ivette S. –
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Marsha A. –
I love this BiEst cream! I have very sensitive skin and this doesn’t bother me at all. I noticed a decrease in pore size after my first bottle and look forward to more results with my second.
Brittany D. –
Really love how fresh and plump my face feels. My dad and sister both asked if I was pregnant because I’ve had that pregnancy glow lately..yay for estrogen cream!!
Kat O. –
So far so good!
MARJORIE M. –
I really like this product and use it every day
Nikki P. –
Fantastic product, makes my pores smaller and i love that it is not full of toxic ingredients.
Bethel H. –
I’ve been using this for a few weeks and like it. Hydrating and slightly skin plumping. Some breakouts when first started but settled down. Too soon to be sure about long term benefits but I plan to continue using for awhile
Camille R. –
I have not had this product less than 2 months now that I’ve been using it. I don’t see any changes as of yet to my skin. I feel it is too early to give a full review, but I will share some thoughts. Initial thought is product is packaged in a beautiful presentation
1. I like the pump it distributes smoothly and is easy enough to control the amount coming out.
2. I don’t like the smell, but in the same thought I am happy there aren’t added chemicals to add smell.
3. The product is light and doesn’t feel heavy on my skin.
4. I like the thought that it can help slow aging process and wrinkling.
5. I don’t use this product alone, I pair it with my usual moisturizer so I can’t speak to how it stands alone moisturizing.
6. The cost is moderate to high but cheaper than botox like injections and if it helps reduce wrinkles and aging process then it is a better value without the frozen face.
7. It’s a popular product so expect a wait plan ahead when you will need to re-order. Once back in stock the company reps were quick to let me know and to ship my order out.
8. The company communicates well from my experience and is responsive and positive.
9. The company promotes this if used on the face will not increase systemic estrogen levels. This is important to me with a family history of breast cancer I can’t take estrogen for HRT. I will take a blood test in a couple of months to see if this claim is accurate for me. I wash my hands after applying to my face to be careful. Hopefully I can come back to this review and give the results when I know if it raised my estrogen levels or not.
Bassey I. –
Love the way it makes my face feel. This is a quality product. Thank you karen
Theresa H. –
Have been using 1 pump per day for 10 days now. Alternating using as a face cream and on my wrists. To soon to tell yet but feels soft on my face.
Zoriana B. –
Yay, yay, yay. I have been wanting to get an estrogen cream that is specifically made for the face to help me with wrinkles and general skin aging. I just started the formula, so will report back with my results, but I can honestly say that the cream feels so luxurious and knowing that there are no nasties and only goodness, like vitamin E, aloe vera and shea butter, make me happy that I am getting a solid safe base.
Thank you Karen for making such a great cream that I trust.
Beverly T. –
great
Theresa H. –
got my products and just started using them
Monica Q. –
I Love this cream!! It’s amazing my skin looks great and my wrinkles are fading!!
Malea M. –
I am loving this cream. I am having less irritability and no more night sweats. I also seem to be sleeping better.
Brandy S. –
Major difference in fine Ines on my face! I had minor surgery on right side of face which ended in stitches, I was only able to apply the cream to one side of my fcae for about 4 weeks and wow you can truly see a difference in the lines, smoothness and over all appearance of my skin! very impressed had no idea or I would have started using years ago!!!
Karen R. –
Amazing product!
Jamie C. –
smells great, goes on smooth and so far my skin looks more vibrant
Mary M. (verified owner) –
I really love how it makes my face feel, my daughter‘s been using it a little bit longer than me and she’s noticed quite an improvement in her overall skin texture and look.
Mary H. –
I have used Biest Estro2 for 9 months, I love it. I’m 69 years old and it has really made a difference in my skin.
Mary Holloway
Rachael A. (verified owner) –
i am 51 years old, perimenopausal, and have been using this AMAZING cream for about 4 months now- just around the time I started on BHRT !! My 50 yo sister had not seen me for a few weeks prior to starting on this cream, and when she finally did, she said, “woaahhh sis! You look so good, your skin! You don’t have those eye wrinkles going on. What are you doing? Using?” I do not do botox, or anything outside of my at simple at home skincare routine–while my sister is all about the regular bi-weekly esthetician visits (lasers, peels, etc). I am not opposed to other modalities of keeping the skin looking great, I just simply do not do it. I am keeping it simple and healthy with Karen Martel’s Bi-Est face cream! My sister just ordered 4 bottles !!
Julia M. –
Have not noticed much, yet.
Jolene C. (verified owner) –
This product is magical – felt a difference immediately! Best way I can describe it is feeling tingly and sparkly after use – love it!
Kristen H. –
I am 54 and since using the cream have been told multiple times that I don’t look older than 35! I use it on my face and neck. Love it!
Lynn J. –
Love this product!
Kristi W. –
Loving this cream! Using it all over ❤️❤️
Jodi L. –
My skin is definitely looking and feeling smoother!
Bryn P. –
Enjoying this!
Lacey J. –
I’ve waited about two months to share my experience because I really wanted to see how it worked. I can say it’s one of the greatest products I have ever bought. It has really changed my skin on my face. It’s brought this youthful juiciness back to my skin. Also, the quantity is extremely impressive. It’s not one of those bottles that’s a quarter full and only last a couple weeks I feel like I’ve been very generous with the pumps and I still have a ton of product left. The quality is worth every penny.
Nancy W. –
I saw and felt a difference in just a couple of days!
Donna H. –
I am not noticing a diffrrrnce in my skin yet. Hopefully in a few more weeks of use.
cindy D. –
After just a few weeks of using, the lines on my face have lessened! I was already taking systemic HRT but adding the face cream was icing on top! Love it!
Renee Marco –
I LOVE these creams! I feel like my old self again!
Katie P. –
It truly is one of the very best products I’ve ever tried. Period. I can actually physically feel the product absorbing and helping to heal my skin. Thanks for creating such a powerful formula, it’s beyond appreciated.
Ann W. (verified owner) –
I use two pumps right after cleaning my face in the morning 20 minutes before makeup. It’s part of my go-to regime before work. Yes, it helps with my super clean low carb, high fat lifestyle.
Skin is healthy and smooth. People who try to guess my age are guessing 10 to 15 years younger that I truly am.
So, thank you, Karen. I am such a devoted fan of you!
Darlene T. –
I have notices a huge difference in my skin since using this product. So good I stocked up so that I do not run out .
Smoother , brighter .
Theresa G. –
Very nice cream, smooth and made my face look and feel good
Jennifer H. –
I love the cream and my skin feels more youthful
Diane H. (verified owner) –
Using Estro2 for HRT. Feeling more like myself since starting using this. After just a couple of weeks my partner began commenting that my skin feels much softer and wanted to know what I was doing different 🤗
sandy z. –
I have been using it for some time now and apply a pea size drop to my face every night. Not sure it has helped shrink my pours as promised, but it does keep my skin looking healthy!
Kat O. –
Love how it’s cleared up my problem skin
Mary M. (verified owner) –
Great product
Tiffany N. –
After using this cream for two weeks now I am so pleased with the feel and look of my face. It has smoothed my fine lines. In addition to the effects I was hoping it would have on my face, I was watching my shoulder blade pain that had persisted even through finishing physical therapy. With the help of collagen peptides and amino acids, I believe the estrogen in this cream has also helped alleviate the pain as well! I am so pleased with this cream and highly recommend it!
Sandra K. (verified owner) –
I love this product! I feel like it’s really helped with the fine lines around my eyes and lips. Ive even been using it on the backs of my hands
Holly B. (verified owner) –
Amazing product! Easy application and rubs in so quickly without any residue or sticky feeling. My skin looks and feels amazing; I love the pure ingredients, and the most fantastic Customer Service Team is quick to respond to any questions you may have; you are never left hanging and in the online world that is a big plus!
Toni W. –
I put it on in the morning with my VC! Love it
Amy S. –
I can tell a great difference in my mood and anxiety is improving.
Christine F. –
Love the consistency. the smell and it works great!
Amy S. –
I’m on my second bottle. I really like this product, it’s very moisturizing and I love that it doesn’t have a harsh sent. I will be purchasing a 3rd bottle when the time comes.
Barbara A. (verified owner) –
This definitely made a difference immediately with my sleep – will purchase again!
Debora S. –
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Norma H. –
I have been using the Bias for a few weeks. It’s quite moisturizing as I needed more moisture while using a copper peptide skin care.
Holly B. (verified owner) –
Fantastic product! Wonderful texture and accurate pump. I have sensitive skin and it is never a problem!
Jamie B. –
Love this cream!
Lindsay T. –
I feel more energized and less groggy since starting the cream.
Carrie B. (verified owner) –
I’ve just started using this each night. Still too early to tell if I ‘feel’ different. I’ve recently been diagnosed with Hashimotos so this on top of medication and a new supplement regime, there’s just too many variables in the mix to really know which is making me feel better.
But I definitely have noticed the improved appearance of my skin on both face and neck. Pores seem smaller and skin just looks smoother.
I’ll definitely keep using.
Heather R –
Beautiful formula, feels great going on , doesn’t clog pores and keeps skin younger
Sheri Clary –
Love this
Lisa –
Love this stuff! My skin feels and looks great just after a week using it. Highly recommended.
Teri Wyse –
I have really enjoyed using the Estro 2rejuvenate cream. I layer it in my AM routine after vitamin C and before sunscreen. It layers beautifully.
Donna Jordan –
Love this product. My face looks amazing. No fine lines feels moisturized. Can say-enough. So glad I found this face cream
Dori Hite –
I love this cream. Under eye area looks so much better.
Kim Pyper –
The cream is so smooth and luxurious! It hydrates and seems to add volume to sagging skin near my mouth. Thank you for making this available to us!
Lindsey Munroe –
It’s my first bottle and I am hopeful for noticeable results.
Leesa Thao –
Very nice
Debbie Lium –
I am 57 and 1 year post menopausal. I lightly rub in 1 pump nightly on face and neck. My skin is much more soft and silky. Felt the difference after couple nights
Highly recommend it
Lynn Pierson –
Love this cream, exactly what I needed for my aging skin – love Karen’s products!
Cathy Eason (verified owner) –
Loving the Estro2 Rejuvenate Face Cream! After just one month of twice daily use I notice my skin is less dry overall, some fine lines are starting to reduce, and some hyperpigmentation is also getting lighter. The cream applies easily and evenly with no greasy feeling and is virtually scent-free. I plan to keep using it as part of my daily healthcare routine.
L Jordan –
I absolutely LOVE this cream! I use it every day on my face and I have also been using a couple days a week on my inner arms. The texture is great, it absorbs very quickly, there is no smell AND it’s affordable which I really appreciate for such a great product!
Susan Townsend –
I have been using the face. Team for several months. I think I can notice a reduction of fine lines around my eyes. The cream goes on smoothly and doesn’t have much of a smell, which I appreciate.
Jessica Thatcher –
This light weight cream absorbs nicely into the face and neck without fragrance or a greasy feel afterwards. Would definitely buy it again!
Kim A Texeira –
Feels great going on skin, not greasy but very deeply moisturizing!
Beth Goldberg –
I use this and the other Estro cream as topical face base cosmetics. What an instant improvement to tone, texture, and glow.
Greta –
This is a great boost. I only use1-2 pumps (half dose) for general well being. I trust Karen and love that I can purchase this product.
Kathie Hamby –
LOVE it! Use every night. Moisturizes so well and the combination estriol and estrodial is such a common sense, simple skin care basic I know is benefiting me greatly as I age. Thanks for making this clean, economical and accessible product!
Julie Peterson –
I’ve been using Estro2 for about 6 weeks and really do like it. I feel like it has helped overall texture and appearance. I’ll be ordering again!
Julie Peterson –
I love this cream! I have always struggled to find a face cream I like but I’ve been using it for a few months and love it! I will be ordering more.
Kellie (verified owner) –
Diane H. –
Feeling more like myself since starting using Estro2. After just a couple of weeks my partner began commenting that my skin feels much softer and wanted to know what I was doing different
Carla (verified owner) –
So far so good! I use it at night and I like that it isn’t super heavy. Too soon to tell if it’s working but I can’t wait to see!
Carla F. (verified owner) –
It’s a little bit too early to tell what is happening with my skin visually, but I love the way it feels on my face and neck at night before I go to bed. Moisturizing yet light. And I know the estradiol and estriol are doing great things for my skin integrity!
Kathleen B. (verified owner) –
Excellent estrogen cream that goes on beautifully! I bought it because dosing amount is clearly stated.
Lori T. (verified owner) –
I had spots on the back of my hands. The dermatologist told they were “wise” spots. I asked how I can get rid of them and the answer was laser. I started using Estro Rejuvenate on the spots and they are gone after 2 weeks! No lasers for me!
Donna (verified owner) –